Reportedly, brain metastases are amongst the most fatal tumor metastases, with an average survival time of less than 1 Year, and the occurrence of brain metastasis is increasing. A new study by researchers from TAU (Tel Aviv University) discovered that melanoma brain metastasis intervenes when tumor cells “take control” on an inflammatory mechanism in the brain. Obstructing this pathway can prevent these metastases from progressing, as per to the researchers. The study was published in the journal Cell Reports and was carried by TAU graduate scholars Dr. Hila Doron and Malak Amer, in partnership with Professor Ronit Satchi-Fainaro.
Professor Neta Erez—from the Department of Pathology at TAU—said, “The prediction of patients having brain metastases is very severe. Earlier patients used to die from metastases but today, treatments have advanced and they are able to live longer, so the occurrence of identified brain metastases is surging.” The researchers utilized a mouse prototype of spontaneous melanoma to analyze the interactions of melanoma tumors in the brain microenvironment. They found that melanoma in the brain progression is promoted by the invasion of an inflammatory mechanism by astrocytes, which are the brain cells that uphold a protected environment in the brain.
On a related note, recently, a new technique was found that may improve diagnosis and treatment of advanced brain cancer. Scientists from Yale Cancer Center have shown a powerful method to examine how tumor cells are changed as they spread or metastasize to the brain. The study was published in the journal Cell Reports and may eventually advance early diagnosis and help in the treatment of metastatic brain cancer, whose occurrence is increasing and whose treatments are naturally limited. Associate Professor Don Nguyen—from Yale Cancer Center—said, “Once tumors spread in the brain, most of the drug therapies are no more effective.” To address this problem, scientists have come up with “xenograft” replicas of metastasis.
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